"Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications" by Monika Asnani, Kim Quimby et al.

Sickle cell disease is a lifelong, inherited disorder which can cause a number of complications throughout an individual's life. It may cause a huge burden on both the patient and their family, including frequent visits to healthcare facilities. The illness causes not just physical complications such as painful crises and strokes, but may have many other effects such as depression, poor quality of life, coping issues and poor family relationships. When people with a chronic illness have better understanding about their illness....Read more

Podcast: Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications


"Adverse effects of biologics: a network meta-analysis and Cochrane overview" by Jasvinder A Singh et al.

Biologics are used for the treatment of rheumatoid arthritis and many other conditions. While the efficacy of biologics has been established, there is uncertainty regarding the adverse effects of this treatment. Since important risks such as lymphomas, serious infections and tuberculosis (TB) reactivation may be more common to the biologics but occur in small numbers across the various indications, we planned to combine the results from biologics used in many conditions to obtain much needed risk estimates ... Read more

"Food supplementation for improving the physical and psychosocial health of socio-economically disadvantaged children aged three months to five years" by Elizabeth Kristjansson et al.

Undernutrition contributes to five million deaths of children under five each year. Furthermore, throughout the life cycle, undernutrition contributes to increased risk of infection, poor cognitive functioning, chronic disease, and mortality. It is thus important for decision-makers to have evidence about the effectiveness of nutrition interventions for young children... Read more

"Education of health professionals for preventing diabetic foot ulceration" by Damian Francis et al.

To investigate the effects of educational interventions on the behaviour and clinical practice of health professionals, and subsequent patient outcomes related to prevention of foot ulceration in people with diabetes... Read more

"Probiotics for fibromyalgia" by Vjekoslava Supraha et al.

To assess the benefits and harm of probiotics for reducing pain and improving function in people with fibromyalgia and its major complications... Read more

"Interventions for treating pulmonary hypertension in people with sicle cell disease or thalassaemia" (protocol) by Andre Bowers et al.

To assess the safety and efficacy of interventions for treating PH in people with SCD or thalassaemia... Read more

"Oral protein calorie supplementation for children with chronic disease" by Damian Francis et al.

Poor growth and nutritional status are common in children with chronic diseases. Oral protein calorie supplements are used to improve nutritional status in these children. These expensive products may be associated with some adverse effects, e.g. the development of inappropriate eating behaviour patterns. This is a new update of a Cochrane review last updated in 2009. ... Read more

"Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognitiong of its related complications" by Damian Francis et al.

To determine the effectiveness of patient- and caregiver-centred educational interventions for changing knowledge and understanding of SCD among patients as well as caregivers of people with the disease.To assess the effectiveness and safety of patient- and caregiver-centred educational interventions and programs for the recognition of signs and symptoms of disease-related morbidity in patients with SCD… Read more

“Interventions for caregivers for the recognition of disease-related complications in children with sickle cell disease” by Ian Hambleton et al.

As the scope of this review question has expanded, this protocol has been replaced by the new protocol 'Interventions for patients and caregivers to improve knowledge of sickle cell disease and recognition of its related complications'. To view the published versions of this article, please click the 'Other versions' tab… Read more

 “Inhaled bronchodilators for acute chest syndrome in people with sickle cell disease” by Ian Hambleton et al.

Bronchodilators are used to treat bronchial hyper-responsiveness in asthma. Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. Therefore, bronchodilators may be useful in the treatment of acute chest syndrome… Read more

“Regular long-term red blood cell transfusions for managing chronic chest complications in sickle cell disease” by Ian Hambleton et al.

Sickle cell disease can cause severe vaso-occlusive crises and dysfunction of most organ systems. The two most common chronic chest complications due to sickle cell disease are pulmonary hypertension and chronic sickle lung disease. These complications can lead to morbidity (such as reduced exercise tolerance) and increased mortality… Read more

"Caribbean Branch” presented by Roberta W. Scherer, PhD (PDF)

 “CARPHA – Preventing Disease, Promoting and Protecting Health” presented by Ms. Carlon Kirton (PDF)

“The Launch of the Caribbean Branch of The United States Cochrane centre, and Symposium – Some Insight into the Cochrane Collaboration’s New Node for the Caribbean  by Luis Gabriel Cuerro Amore (PDF)

 “Developing and using Evidence to Make Motherhood Safer in Jamaica” by Affette McCaw-Binns, MPH, PhD (PDF)

 “Incorporating Research Findings into Policy” by Jeremy Grimshaw (PDF)

“Translating Research for Policy Impact and Practice – Developing Clinical Guidelines: An Evidence Based Approach” by Peter Tugwell (PDF)

“Information Overload and Today’s Clinician: The Role of Evidence-Based Healthcare” by Roberta W. Scherer, PhD (PDF)